This guide, from the Tobacco Control Network, offers the evidence and rationale for a policy-based approach to reduce tobacco use. It also provides (1) principles for advancing tobacco control policies and working with Tribal nations and (2) a summary of the changing tobacco control landscape, including the youth e-cigarette epidemic, information on health disparities and health equity, and addressing related issues such as marijuana, e-cigarette or vaping use-associated lung injury (EVALI), and COVID-19.